After being a teacher, she became a reformer and started to focus on temperance and slavery. Then she started to go to the Sons of Temperance meetings and she joined the anti-slavery movement. When she went to the Sons of Temperance meetings, she along with the rest of the women who went to the meetings were not allowed to talk. Instead of going to the Sons of Temperance, she started her organization named the Women's State Temperance Society. Besides that organization, she started many associations by herself and with her life long friend, Elizabeth Cady Stanton. Elizabeth also had a great influence on Susan because they had the same interests. One interest which they worked hard for was women's rights. Elizabeth and Susan had said that they wanted "justice for all". This meant that they wanted the equal rights for white and black, women and men. In the end, Susan died at age 86.

 Susan had lots of associations she started and some she started with Elizabeth Stanton. Some of these associations were the National Women Suffrage Association which they started in 1869 and the American Equal Rights Association. Susan and Elizabeth helped form some associations also, like the Working Women's Association. From 1851 to 1900, they were also the strongest leaders. Also, Susan got her self a spot in history and her face on the first dollar coin.